Search on:
KININOGEN, HIGH-MOLECULAR-WEIGHT
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Kininogen, High-Molecular-Weight
Descriptor
Spanish
:
Quininógeno de Alto Peso Molecular
Descriptor
Portuguese
:
Cininogênio de Alto Peso Molecular
Synonyms
English
:
Fitzgerald Factor
HMWK
High Molecular Weight Kininogen
High Molecular Weight Kininogens
High-Molecular-Weight Kininogen
High-Molecular-Weight Kininogens
Kininogen, High Molecular Weight
Kininogens, High Molecular Weight
Kininogens, High-Molecular-Weight
Tree Number:
D12.644.276.812.654.350
D12.776.124.125.635.480
D12.776.467.812.654.350
D12.776.811.420.350
D23.119.630.480
D23.469.050.375.425.350
D23.529.812.654.350
Definition
English
:
A
plasma
protein,
molecular weight
of 110 kD, that normally exists in
plasma
in a 1:1 complex with
PREKALLIKREIN
. HMWK is split by
plasma kallikrein
to produce
BRADYKININ
. The complex is a cofactor in the activation of coagulation
factor XII
. The product of this reaction, XIIa, in turn activates
prekallikrein
to
KALLIKREINS
. (From Stedman, 26th ed)
History Note
English
:
98; use KININOGENS 1989-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33486
Unique Identifier:
D019679
Occurrence in VHL
:
Similar:
DeCS